Understanding Atrial Fibrillation: Genetics and Causes
Atrial fibrillation (AFib) is a typical heart condition affecting millions in the U.S.A., as per the Center for Disease Control and Prevention. It is a kind of irregular heartbeat that will increase the risk of stroke, heart failure, and other heart-related complications. While lifestyle factors such as diet, exercise, and stress can contribute to AFib, a 2003 study by Fox and coworkers has also shown that genetics play a role in the development of this condition.
In this article, we’ll explore the underlying genetic causes of AFib and how understanding these causes leads to more effective treatments. We will also discuss how medications such as Eliquis 2.5 mg tablet, available for purchase from Canadian pharmacies help.
The Genetics of AFib
AFib is a condition characterized by irregular heartbeats, leading to various symptoms, including palpitations, shortness of breath, fatigue, and dizziness. In some cases, AFib can also lead to more serious complications such as stroke and heart failure.
There are several genetic mutations that are associated with a higher risk of developing AFib. Some of these mutations affect the genes that regulate the heart’s electrical activity, which can cause abnormal heart rhythms. Other mutations affect the structure of the heart, which can boost the chance of developing AFib.
One example of a gene that is linked to AFib is the KCNQ1 gene, which regulates the flow of potassium ions in and out of heart cells. These gene mutations have been demonstrated to raise the chance of developing AFib, particularly in individuals who have a family history of the condition.
Another gene that is associated with AFib is the SCN5A gene, which codes for a protein that helps regulate the flow of sodium ions in and out of heart cells. Mutations in this gene can cause abnormal heart rhythms, which can cause AFib.
While genetics play a role in the development of AFib, it’s important to note that lifestyle factors also play a significant role. Risk factors for AFib include high blood pressure, obesity, diabetes, and excessive alcohol consumption. By addressing these risk factors, individuals are able to reduce their risk of developing AFib and other heart-related conditions.
Inherited Conditions that Cause AFib
In addition to genetic mutations, there are several inherited conditions that can boost the chance of developing AFib. These conditions often affect the structure or electrical activity of the heart, leading to abnormal heart rhythms.
One example of an inherited condition that can cause AFib is hypertrophic cardiomyopathy (HCM). HCM is a condition where the heart muscle becomes thick and stiff, making it harder for the heart to pump blood effectively. This results in a risk of developing AFib, as well as other complications such as heart failure and sudden cardiac arrest. HCM is often inherited in an autosomal dominant pattern, meaning an individual only needs to inherit one copy of the mutated gene from one parent to develop the condition.
Another inherited condition that can cause AFib is long QT syndrome (LQTS). LQTS is a condition where the heart takes longer than usual to recharge between beats, leading to irregular heartbeats. This is more likely to increase the risk of developing AFib, as well as other complications such as fainting and sudden cardiac arrest. LQTS can be inherited in an autosomal dominant pattern, although it can also occur sporadically without a family history.
Brugada syndrome is another inherited condition that can cause AFib. Brugada syndrome is a condition where the heart’s electrical signals are disrupted, leading to irregular heartbeats. This can amplify the risk of developing AFib, as well as other complications such as sudden cardiac arrest.
While inherited conditions can increase the risk of developing AFib, it’s important to note that not everyone with a genetic mutation or inherited condition will develop.
The Role of Genetics in Treatment
Understanding the genetic causes of AFib will lead to more effective treatments. For example, medications such as Eliquis, which are blood thinners, help prevent blood clots that can lead to stroke in individuals with AFib. However, certain genetic mutations affect how well these medications work or boost the chance of side effects.
By identifying genetic mutations that affect an individual’s response to certain medications, healthcare providers will tailor treatment plans to better meet the individual’s needs. This will improve the effectiveness of treatment and reduce the risk of side effects. Additionally, genetic testing also helps identify family members who are at increased risk of developing AFib, allowing for earlier intervention and treatment. Understanding the role of genetics in AFib ultimately leads to better outcomes for individuals with the condition and their families.
How Does Eliquis Help?
Eliquis is a medication that is commonly prescribed to individuals with AFib to help reduce the risk of stroke. The medication works by preventing blood clots from forming in the heart, which can travel to the brain and cause a stroke. Unlike other blood thinners, Eliquis is more effective at reducing the risk of stroke while also being associated with a lower risk of bleeding complications.
It is typically taken orally twice a day, and you have to choose between Eliquis 2.5 mg and Eliquis 5mg tablets based on your prescription. While Eliquis is generally well-tolerated, individuals with certain genetic mutations are at risk of side effects, and their dosage needs to be adjusted accordingly.
Ordering Medications from Canadian Pharmacies
An online Canadian pharmacy is an excellent option for individuals with AFib looking to order medications such as Eliquis. Many medications are more affordable in Canada due to government regulation of medication prices. Additionally, Canadian pharmacies like Polar Bear Meds provide online ordering, making ordering medications more convenient for individuals who have difficulty accessing local pharmacies or need to order medications in bulk. However, it’s important to ensure that any pharmacy you order from is reputable and licensed.
When ordering medications from Canadian pharmacies, do your research and make sure you are ordering from a legitimate pharmacy. Look for the best Canadian online pharmacy that is licensed by the Canadian International Pharmacy Association (CIPA) or the International Pharmacy Association of British Columbia (IPABC). Also, ensure that the pharmacy you are ordering from is reputable by checking the customer ratings and reviews. Finally, make sure you understand the regulations around importing medications into the U.S.A. and follow any necessary steps to ensure that your medications are legally imported.
AFib is a complex condition that has multiple underlying causes, including genetics. Understanding the genetic causes of AFib leads to more effective treatments, including medications such as Eliquis 2.5 mg tablet that is available for purchase from Canadian pharmacies. By tailoring treatments to an individual’s specific genetic makeup, doctors will provide more personalized care for individuals with AFib.
While Canadian pharmacies like Polar Bear Meds provide affordable and convenient options for ordering medications, it’s important to ensure that any pharmacy you order from is reputable and licensed. If you have concerns about your medications or treatment plan, speak with your healthcare provider.